Articles

Oxycodone: What You Need To Know

August 25, 2019


Oxycodone is a semi-synthetic opioid which
has been used since the early 1900s.
It is one of the most common opioids in medical
settings and is widely taken for recreational
reasons as well.
Since the introduction of OxyContin, a controlled
release form of the drug, its use has increased.
The positive effects include euphoria, pain
relief, mood lift, music enhancement, relaxation,
sedation, and anxiety reduction.
Among the negative effects are drowsiness,
nausea, vomiting, constipation, cognitive
impairment, dizziness, and respiratory depression.
Variation exists in a notable way with the
recreational effects.
Some people receive a lot of euphoria, while
others do not.
When the euphoria exists, it can be similar
to what’s provided by morphine and heroin.
And the drug is capable of causing a “nod,”
which is a heavily sedated, often euphoric
state, sometimes accompanied by waking dreams.
It tends to be less sedating than other opioids
and it can either facilitate sleep or cause
insomnia.
In medical settings, the most common negatives
are nausea, drowsiness, and constipation.
All of those can decline over long periods,
though constipation persists more than the
others.
Combining oral oxycodone with oral naloxone
may reduce the constipation.
There are many applications for Oxycodone
that have been realized and it is commonly
prescribed for acute post-operative pain,
chronic cancer pain, and, more controversially,
chronic noncancer pain.
It is effective, to varying amounts, in most
cases of pain.
One of the least controversial uses for it,
is in acute pain.
Prescribing it for long periods of time in
cancer patients is also not terribly controversial
and its efficacy is pretty similar to morphine.
In other chronic cases, there are patients
who receive benefit for years and dose increases
are minimal after the first 3 months.
Yet, there is ultimately a lack of evidence
for its long-term efficacy and it isn’t risk-free,
so there’s usually an emphasis on trying alternative
treatments.
Others cases where it may have some application
include visceral and neuropathic pain.
Oxycodone compares favorably to morphine in
some ways.
They offer a similar level of pain relief,
while Oxycodone causes fewer hallucinations,
may be less likely to cause drowsiness, and
often causes less itching due to lower histamine
release.
Overall, they have very similar effects in
overdose.
The drug works in 10 to 30 minutes and lasts
for 4 to 6 hours when an instant release product
is used
With a controlled release product, the onset
is around 30 minutes and the effects may last
up to 12 hours.
Many people find it only lasts for 6 to 10
hours.
Intranasally, the onset is 1 to 5 minutes
and the duration is 3 to 5 hours.
Oxycodone is a semi-synthetic opioid synthesized
from thebaine, which occurs naturally in Papaver
somniferum.
Like morphine, codeine, and hydrocodone…oxycodone
is in the phenanthrene class of opioids.
It appears to exert much of its activity through
the mu-opioid receptor, though actions at
delta and kappa have not been entirely ruled
out.
Some limited research shows kappa-opioid receptors
may be contributing to some kinds of pain
relief.
It was even suggested at one point that oxycodone
primarily operated through kappa receptors,
but that doesn’t seem accurate.
A significant level of dopamine release is
also triggered in the nucleus accumbens and
perhaps to a greater degree than morphine.
The differences between Oxycodone and Morphine
in this area haven’t been fully explored.
Compared to morphine, Oxycodone has a lower
affinity at the mu-opioid receptor, but this
is counteracted by greater availability in
the brain.
On the pharmacokinetic side, it is primarily
metabolized to noroxycodone, but a smaller
portion also becomes oxymorphone.
Oxymorphone and another metabolite, noroxymorphone,
have been put forth as possible contributers
to oxycodone’s effect.
With the available research, Oxycodone itself
seems to be most important, with its metabolites
playing little to no role.
Oxycodone is available from 5 to 30 mg and
controlled release products range from 10
to 80 mg.
In medical settings, a common dosing regimen
is 5 to 10 mg every 6 hours.
In non-medical settings, a light instant release
dose is 2.5 to 10 mg, a common dose is 10
to 25 mg, and a strong dose is 25 to 30 mg.
For controlled release, a light dose is 10
to 20 mg, a common dose is 20 to 40 mg, and
a strong dose is over 40 mg.
Intranasally, a light dose is 2.5 to 5 mg,
a common dose is 5 to 15 mg, and a strong
dose is 15 to 25 mg.
Researchers at the University of Frankfurt
in Germany synthesized Oxycodone from thebaine
in 1916.
During the same year, tests were conducted
in animals to investigate its efficacy as
a pain reliever.
Between those tests and some trials in humans,
it was found Oxycodone could offer a slightly
greater level of pain relief than morphine,
had a longer duration of action, and produced
less nausea, drowsiness, and depression of
the circulatory and respiratory systems.
Clinical use in Germany began between 1917
and 1919.
It was introduced by Merck under the name
Eukodal and was mainly used for acute pain.
Within a few years, reports had already appeared
describing the drug’s euphoric and recreational
effects.
Dr. Hans Kreitmair, one of the top pharmacologists
at Merck, began studying a combination of
scopolamine, oxycodone, and ephedrine in the
mid-1920s.
That combination reportedly produced intense
and long-lasting sedation and pain relief,
while not affecting vital signs.
Clinical trials of the combo, called SEE,
soon started.
SEE entered the German market in 1928.
SEE was popular in Germany and Central Europe
during the 1930s, but its greatest use came
during World War 2.
Prior to the War, surgeons were using it for
sedation, pain relief, and amnesia.
Some of the most influential research into
SEE was conducted by Dr. Martin Kirshner,
who ended up promoting SEE.
Around 1938, Wehrmacht, the German Armed Forces,
adopted the combination, referring to it as
“Kirschner’s injection.”
The drug was used during minor and major procedures
to provide pain relief.
Merck sold 2 million ampules of SEE to German
Armed Forces during the course of the War.
Some surgeons in Germany weren’t fans of the
drug and suggested it’d be better for morphine
and methamphetamine to be used instead.
Concerns about SEE led one part of the Army
to abandon it, and by 1945, the German forces
were using it far less.
Most of the decline came from production and
distribution problems caused by Allied bombings.
After the War came to an end, the product,
then known as Scophedal, was still used to
a limited degree by surgeons in Germany, Austria,
Switzerland, and Scandinavia.
Production ended in 1987.
Oxycodone entered the US market in the late
1930s, but it took over a decade for use to
really increase.
The first widely used product, known as Percodan,
was introduced by Endo Pharmaceutical in 1950.
It contained oxycodone and aspirin.
While concerns about the over-use of Oxycodone
are usually connected to the 2000s, a similar
situation developed in the 1950s and 1960s.
Percodan’s manufacturer was accused of downplaying
the harms, doctors were accused of over-prescribing,
and some people felt Oxycodone was ruining
lives.
This situation was obvious in California.
Percodan initially carried a relatively severe
warning, which stated:
“The habit-forming potentialities of Percodan
approach those of morphine more closely than
those of codeine.
The same care should therefore be exercised
when using Percodan as when morphine is prescribed.”
That warning was eventually dropped and simply
replaced with, “may be habit-forming.”
At the same time, the US production of Oxycodone
jumped from 9 kilograms around 1950 to 569
kilograms in 1960.
Campaigners appeared in order to fight the
drug and they had four main arguments:
1.
Oxycodone is being prescribed too much and
for too many conditions.
2.
People with no history of addiction or crime
are becoming addicted and committing crime.
3.
“Thousands of tablets are being diverted into
illegal channels” and “California is faced
for the first time in its history with the
problem of underworld sources actively seeking
an otherwise licit narcotic as a substitute
for heroin.
And
1.
Other ingredients in Percodan, such as Aspirin,
could have their own negative effects when
used at high doses.
Chief of California’s Bureau of Narcotic Enforcement,
John Storer, said:
“People are eating Percodan as though it were
popcorn, with extremely telling effects.”
One of the proposed reasons for California’s
allegedly out-of-control Oxycodone use was
that:
“California has an undue share of unstable
personalities who welcome bizarre methods
of escaping reality”
Forged prescriptions were found to be very
common around Los Angeles and San Francisco.
The drug’s widespread use in California continued
through the 1960s.
It was also popular in other countries, both
in medical and non-medical settings.
In 1954, an estimated 11.5% of narcotic misuse
in France was attached to Oxycodone.
One source wrote:
“This substance, which began to be used in
France only a few years ago, has proved to
be particularly dangerous with regard to drug
addiction.
It seems to act more like heroin than like
morphine.”
And in the 1960s, it became the top injectable
opioid for operative pain in Finland.
The modern history of Oxycodone in the US
begins in the 1980s.
New oxycodone products entered the market
around this time and its use for severe pain
increased due to the availability of oxycodone-only
products.
Prior to the 1990s, the overall use of Oxycodone
was still relatively low and abuse didn’t
receive much attention.
Codeine and Pethidine were more significant
members of the market.
The use of oxycodone increased significantly
following OxyContin’s release in 1996.
Between 1996 and 2005, production, prescribing,
and non-medical use all increased.
Part of Oxycodone’s rise among recreational
users in the early 2000s was tied to the easy
extraction of the drug from Oxycontin.
Marketing by Purdue, the maker of Oxycontin,
helped increase prescriptions for chronic
cancer pain and for non-malignant pain.
In some cases, the drug’s efficacy was overstated
and the harms may have been minimized.
Even now, people tend to believe prescription
opioids are safer than they actually are.
Deaths attributed to Oxycodone increased from
14 in 1998 to 1,007 in 2006.
In 2007, Purdue pled guilty to providing misleading
information about OxyContin to regulators
and prescribers.
The settlement cost the company hundreds of
millions of dollars, though Purdue has made
billions from the drug.
An attempt to reduce non-medical use came
in 2010, when the FDA approved OxyNeo, a reformulated
OxyContin that was harder to tamper with for
recreational purposes.
OxyNeo fully replaced the old version by late
2011.
While this appears to have decreased the non-medical
use of controlled release Oxycodone, many
people simply moved to instant release oxycodone,
other prescription opioids, and black market
heroin.
Since the 2010s, there has been a push in
multiple countries to change prescribing practices.
Many people in the medical establishment believe
limited supplies should be provided in acute
cases, with patients receiving enough Oxycodone
for days rather than weeks.
And in chronic cases, they believe other drugs
and non-drug therapies should be promoted
with the goal of reserving Oxycodone for cancer
pain, severe pain, and treatment-resistant
pain.
Currently, the controlled release version
is widely used for chronic pain and the instant
release version is taken for acute and breakthrough
pain.
Oxycodone is Schedule 2 in the US.
It is usually controlled elsewhere.
The negative effects of Oxycodone at common
doses are moderate, but overdoses can be severely
dangerous.
Drowsiness, nausea, and constipation are the
kind of negatives seen with common medical
doses.
When an overdose occurs, significant respiratory
depression, consciousness impairment, coma,
and bradycardia or tachycardia can occur.
Respiratory depression can lead to death.
Death is possible without any combinations,
but using other CNS depressants greatly increases
the chance of harm.
When respiratory depression occurs, mechanical
ventilation could be necessary, though the
standard response to an overdose is naloxone.
More naloxone may be required for overdoses
involving controlled release oxycodone.
Two problems associated with long-term use
are depression and cognitive impairment, the
latter of which seems to be correlated with
dose.
Using an amount in the hundreds of milligrams
carries the risk of some form of impairment.
Another issue with long-term use is hyperalgesia,
which is effectively a lowering of the pain
threshold that allows previously unproblematic
stimuli to become painful.
The actual prevalence of this problem is unknown,
but it’s clearly the case that very high doses
for months or years carries the risk of making
someone’s problem worse.
Tolerance to the recreational effects usually
develops within a few weeks and it may occur
sooner, with the onset varying by user.
Using the drug for a long period of time will
result in physical dependence, including the
existence of withdrawal, which includes nausea,
insomnia, sweating, anxiety, restlessness,
muscle aches, diarrhea, and tachycardia.
As was previously mentioned, the acute risks
of oxycodone are significantly increased when
combined with depressants like benzodiazepines,
other opioids, and alcohol.
If you have any questions, feel free to leave
them in the comments section.
In order for The Drug Classroom to provide
more education, support is necessary.
And the best way to support is through Patreon,
at patreon.com/thedrugclassroom.
You can also contribute through PayPal or
Bitcoin.
You can connect with me on Twitter @SethAFitzgerald
and via email at [email protected]
More information and links to references can
be found on the TDC website using the link
below.

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100 Comments

  • Reply Paa Hawkins December 6, 2018 at 12:49 pm

    Just took my first one for a toothache. We'll see.

  • Reply StonerDloner December 7, 2018 at 1:15 am

    I got a question, is the slang term for this drug called Tec?? Or is that a different thing?

  • Reply Majoras Love December 7, 2018 at 5:23 pm

    I was given these but I never took them due to fear of addiction

  • Reply Racing Prospector December 13, 2018 at 8:26 pm

    All you people think it's a good thing because you are in pain, I did 2. It led me to 7 years of heroin. It will do the same to you. Better options

  • Reply Sony Manyu December 15, 2018 at 1:12 pm

    Sir Can you make videos on how to make opium substances… Like morphine, codeine etc… Ty

  • Reply Luke L December 17, 2018 at 8:40 pm

    literally spend hours researching on google to find less information about this drug than you just explained in 12… thankyou

  • Reply Vein Banger93 December 24, 2018 at 4:45 pm

    I'll be honest, I take these and hydros due to personal pain and to get over my self esteem. Yep, I got a addiction.

  • Reply Daniel Reyes January 6, 2019 at 10:32 pm

    I take percocets 10/325mg for my chronic pains on my lower bak lumbar,spine,n i got a very bad herniated discs on my neck..i do have the rite to take this med,but i never abuse it at all.

  • Reply JBIRD NELSON January 7, 2019 at 8:36 pm

    I'm allergic to opiates so I rely on 🌿…..lol 😀
    I can only get synthetic meds for pain….

  • Reply a moon January 9, 2019 at 7:12 pm

    Thank you for the info. Its ridiculous how difficult it is to get unbiased information about drugs. I just got my tonsils out yesterday and was looking for more information about my prescriptions, and your channel has been the best source thus far.

  • Reply BRANDON HARRIS January 11, 2019 at 6:15 pm

    Heroin better

  • Reply FruityPebs January 15, 2019 at 1:12 am

    Oxycodone is such a wonder-drug.

  • Reply Sarah W January 16, 2019 at 7:17 pm

    I occasionally take oxycodone when my pain is really bad. I take slow release and immediate release but only when I really have to. I can take it or leave it – I don't feel a need to have to take it every day. It is a good pain killer but it makes me feel a bit sad/melancholic. It certainly doesn't make me feel 'euphoric' at all.

  • Reply christopher st.marin January 18, 2019 at 8:46 am

    Nice video. Been on it off and on for many years. Cancer. Nerve damage etc. I've never had any problems with it. I guess I'm one of the few.

  • Reply How to Medicate January 20, 2019 at 5:06 pm

    Nice video, very clear!
    I also made an information video on how and when to use oxycodone! haha.

    Keep it up!

  • Reply Natalia Livonof January 25, 2019 at 12:44 am

    i take Oxicontin and oxinorm 6 time's evry day, and it is the best pills against pain for me, belive me i did try many things, but for me it also have 2 really bad site effekt, 1 you are dependene on them like drugs, 2 i sewat like a pig evry time i try to do something, all my body get wet of sweat if i try to clen or move even small things and i hate this sweating part.

  • Reply Ben Smith January 25, 2019 at 1:19 am

    Could you please do a vid on dilaudid ? And maybe how to get around the oros. Please.

  • Reply Willam Tomczak January 25, 2019 at 7:58 pm

    I part of are drug problem

  • Reply Kat nip January 26, 2019 at 10:24 pm

    Oxycodone does not work for me.

  • Reply Michael Epps February 2, 2019 at 6:30 pm

    I jus took 15 mg recreationaly with a fat blunt and i must say….good meds lol

  • Reply lbbradley55 February 11, 2019 at 4:35 pm

    I have been percribeb Powerful Opiates for yrs. I have had Cancer & I am waiting on test results for CANCER test now. But I must say I had many bad Injuries & never took any opiate for them. I even turned down Morphine after a Chest Tumor Surgical procedure. Dr could not believe it. Yrs
    Latter I had back injuries & Dr percribeb loritab 10 I only took them on Weekend for yrs. Dr called me stingy Because I never needed refills. ?
    Then I was in car Wreck & put in Traction & back locked up. ! Then they found Carcinoid Cancer….! I was then given the BIG GUNS..
    & I am awaiting test results for CANCER Return but it Burns my Liver to take Morphine ER 60 & Oxi. I now have Liver DAMAGE from PAIN MEDS… you don't want this…
    If you continue to take them they will Kill You !

  • Reply Ashby03 February 12, 2019 at 5:41 am

    I’ve had my share of oxy and if I pop 2 I throw up and if your pills last 6 hours I want that ones I took last 2

  • Reply Manuel Hernandez February 12, 2019 at 8:17 am

    Constipation with oxy is the major side effect

  • Reply Paul The psn gamer February 21, 2019 at 10:28 pm

    This helps with pain from brain tumor

  • Reply Jose Felix February 28, 2019 at 9:11 am

    I feel like when you do opiates you experience an odd pleasure, but you cant replicate it if you try. Opiates basically give your brain blue balls

  • Reply Desmond John March 5, 2019 at 6:36 am

    Hi Seth, love your videos always! Are you ever planning to do one on heroin? Thanks!

  • Reply Claire Carroll March 6, 2019 at 2:53 pm

    i got my tonsils removed and was prescribed this and it actually helped so much! i would always fall asleep though but sometimes not

  • Reply tec61 March 7, 2019 at 2:21 pm

    I am on 120mg 30mg’s 4 times daily Of OXYCODONE for HERNIATED & BULGING DISCS. I am 57 yrs old & NEED it for work HARD PHYSICAL LABOR. I DO NOT ABUSE IT! THE IDIOTS who DO are making it VERY DIFFICULT for US people who NEED it to get it.🤬😡🤬😡

  • Reply PuertoRicanPower 9301 March 14, 2019 at 8:09 pm

    I would get extremely angry when coming down on oxys and something bad happens, very similar to how they describe hitler when he would get angry, he reportedly got a shot of Eukadol(Oxycodon) every day..

  • Reply Kevin Miedema March 15, 2019 at 12:52 am

    the legal system is hilarious if your a multibillion dollar company. …. you can make more money by not following it and just taking the legal hit.

  • Reply Dorq March 17, 2019 at 12:47 am

    I definitely didn't snort this a couple hours ago

  • Reply Call me Ishmael March 17, 2019 at 10:16 am

    Just make it all legal otc. The dumbasses will od and weed themselves out…..then no more problem

  • Reply Euphoristic Audiosurf By The Fromzzz March 17, 2019 at 12:36 pm

    About the differences: I read Oxycodon does not give a “flash” like heroine when injected in a vein Is that true?

  • Reply MrChillifresser March 17, 2019 at 6:26 pm

    I once had some of those and took 65mg of it without a tolerance that was waaaaay to much i crushed the pills up too
    really dont take more than a max of 30 mg recreationally otherwise its really not that pleasurable and a waste

  • Reply Giovanny Padilla March 19, 2019 at 7:31 am

    So is it safe to say that ALL Instant Release Oxycodone hcl pills of ANY MG is NOT tamper proof and can be Snorted and or injected? Thanks for the great video hope you can answer my question

  • Reply george kelly March 19, 2019 at 2:00 pm

    I've been on them for 20 yrs. I hate them! I'm currently trying to get off them. I don't understand why anyone wants to take them to get high. I work so no time for treatment centers. I have to do this gradually. I'll be glad when I'm off them!

  • Reply SednaFTW March 20, 2019 at 7:13 am

    pills are cheap and people are addicted. heroin addiction is down
    they make oxycontin hard to get, crack down on prescriptions
    heroin goes up.
    they crack down on theroin coming in, make the pills WAY harder to get
    heroin prices goin up, crime goes up. Fentanyl comes in to alleviate the shortage and high prices
    ODS up, addiction up at an all time high ,ect.
    AND THEY WANT TO MAKE THEM HARDER TO GET! AS MORE PEOPLE WHO NEED THEM CANT GET THEM

    Im not saying there shouldnt be regulation but over regulating is a joke. It would be better if 30mg oxyocodnes were the common "$10 bag" people get of heroin. They go for $30 now and aren't sold near as much as heroin and people who need them cant get them. They're so rare now, and fentanyl is so bad it's almost as if they just are completely braindead. They're probably banking out off the heroin and fentanyl coming in somehow.

  • Reply Fuggin Wat March 21, 2019 at 2:24 pm

    >unstable personalities in California
    They're called degenerates.

  • Reply Edward Hester March 24, 2019 at 3:40 am

    Oxy 80s…god they fucked me up good

  • Reply Tessa Logan March 27, 2019 at 7:37 pm

    It's a good tablet until you stop

  • Reply Tessa Logan March 27, 2019 at 7:38 pm

    And no i don't touch it

  • Reply DXMdad March 29, 2019 at 12:32 am

    What’s the ld50

  • Reply sara venr March 31, 2019 at 10:04 am

    I just snorted 100mg and swallow 100mg am I gonna die if I take one more lol

  • Reply Barb L April 5, 2019 at 8:12 pm

    A comment to all pleasure/drug seekers out there: your antics are ruining the lives of pain patients. We are being lumped into the same cohort as you, making it very hard to get our legitimate meds. The pain has actually resulted in suicides. I hope that bothers you: it means you still can care for someone other than yourself and your highs.

  • Reply Deth Meddl April 6, 2019 at 12:25 am

    When I look out of my window, I see the headquarters of Merck 😀

  • Reply Jack Sutherland April 7, 2019 at 4:21 am

    Used properly, it helps a lot of people that live with terrible pain. And because of incompetent politicians trying to stoke any bullshit issues to build their careers and personal gain, people that legitimately need these drugs can't get them so they buy shit off the street. And many die!
    Abuse will turn you into an enslaved dope fiend quicker than shit! All of your money, soul, and passion for life goes right in the toilet.
    Don't even fuck around with any of that garbage. You'll regret it big time!
    If you have seen the many lives ruined that I have, you wouldn't go anywhere near any of that shit.
    I just lost a lifelong friend a couple weeks ago from jabbing himself with heroin.
    Or God knows what that street shit really is.
    No one knew he was doing it till the first sign of trouble being a one way trip to the cemetery!
    The shit is everywhere, and people are really good at hiding it until they are discovered to be glued to their bathroom floor dead as a door nail.
    I love hearing about pushers taking bullets! If anyone ever deserved it, it's a junk peddler.

  • Reply Darksythe King of memer's April 11, 2019 at 6:44 am

    When I was passing my kidney stone they gave me these they knocked me out.

  • Reply Deon Dorsey April 11, 2019 at 1:09 pm

    My podiatrist prescribed me oxycodone two days ago after my foot surgery. I take it every six hours.

  • Reply Rob Cosentino April 14, 2019 at 6:48 am

    Also note that tolerance doesn't generally subside. If you become tolerant, you will most likely remain tolerant.

  • Reply MeatSim64 April 16, 2019 at 5:51 am

    Red Vein Kratom produces the same effects as this drug, it's non-addictive and no nasty withdrawal symptoms. It's unreal how scared the pharmacies are because of this wonderful plant.

  • Reply eat my ass April 20, 2019 at 2:47 am

    oxys never worked on me. Percocets and kratom are what work best for me

  • Reply Commander Vile April 24, 2019 at 2:15 am

    Seen so many young people, friends and family die because of this shit, back when they were handing it out like candy, and I too was hooked on this stuff while I was never educated on how they work and what kind of physical/mental affects they would have. Not only are they expensive and dangerous, if the doctors decide to cut you off for any reason, guess what? You're spending hundreds of dollars on the street, selling all of your possession, your body, or getting hooked on heroin. Educate yourselves, too much of a good thing is always a bad thing, and if possible, look into more natural and healthier options such as Kratom and CBD oil, even Marijuana.

  • Reply killer April 24, 2019 at 9:25 am

    The 20 minutes rapid onset makes it all that much more better. Compared to other opioids Oxycodone is just in its own league. Can easily do 20-40mg and have no problems functioning.

  • Reply ezra limm April 24, 2019 at 11:09 am

    4:20 "In non medical settings" hahahaha

  • Reply adam sala April 27, 2019 at 10:26 pm

    Very addictive only problem with this drug.

  • Reply Susie Shobe May 1, 2019 at 12:53 pm

    I got this for an out patient surgery. They got me in and decided to cancel and take another approach. I was let go. I couldn’t hardly walk . I had had a small stroke 5 yrs ago and acquired a slight on going issues of balance. That could be why it really had such an affect on my gate.. it made me pleasantly content and sleepy.. I was down till the next day. I would think that depressed people, people with mental issues, people with disorders that affect their function in society, would love this stuff.Anyone who functions normally and is in touch with their life would not do this to themselves repeatedly unless they were in horrible pain and could not take part in society and life in general any longer.

  • Reply Misho May 4, 2019 at 3:51 am

    @Robert Bailey 
    Well said Sir, l started like him 15 years ago, now l am swallowing 20+ "Oxy Norm" (fast release) capsules per day and SMOKING up to 10 – 80mg. "Oxy Contins" EVERY DAY !!!
    MY LIFE REVOLVES AROUND OXY's !!!

    I thought TOO that l can control them, it's only a time which will prove that THEY ALWAYS WIN !
    DON'T PLAY WITH A DEVIL !
    You CAN'T beat the Oxys, they a worse than heroin.
    For years l was on low doses – increasing gradually,
    NOW THEY ARE DOING NOTHING TO ME, NO "HIGH" AT ALL, I AM TAKING THEM JUST TO STAY ALIVE !

    In no time (it takes years) but eventually they will destroy your life !

    I PRAY EVERY DAY TO DIE, THIS IS NOT LIFE ANYMORE, IF I CAN TURN BACK TIME, I WILL NEVER TOUCH THAT SHIT – NEVER – EVER !

    And don't be so confident about your will power, at the end – THEY will win !
    (You remind me on myself 15 years ago, that's why l am writing this) !

    Do you think l've started on 1,5 grams per day from day one? No, l started like you thinking that l can control them.
    They proved the oposite.

    DON'T USE THEM ! – stop while you still can.
    After it might be too late !

  • Reply Misho May 4, 2019 at 4:31 am

    Where to find that Red Vein Kratom?
    Is it legal?
    Started on low doses of Oxys 15 years ago, (after a broken back and neck injury) – now I am on 1,5 – 2 grams per day.
    MY LIFE IS HELL!
    P.S.
    Anyone with ANY experience with Red Vein Kratom?
    PLEASE HELP !!!

  • Reply Kara and Lena May 8, 2019 at 12:05 am

    I took two before school today.. school was 100x better 😂

  • Reply Anonymous User May 20, 2019 at 9:57 am

    Lifesavers for people who really need it.

  • Reply ASGOOO May 25, 2019 at 5:52 pm

    is it possible that i cant get euphoria from opioids? i have used 25mg IR Oxycodone without tolerance and i barely felt anything. i have tried Codeine in the past too, same thing

  • Reply Mark Saville May 26, 2019 at 7:21 am

    Excellent video. A good read is 'Blitzed', about drug use in the 3rd Reich. Eukodal gets a few mentions including the telling sentence: "Those who try Eukodal never stop using it." The real eye opener is that Blitzkrieg was driven by and more or less invented by Pervitin AKA Chrystal Meth

  • Reply nxdsrz May 29, 2019 at 5:20 pm

    do oxymorphone aka opana

  • Reply John Keith June 2, 2019 at 8:08 am

    This drug is powerful & extremely addictive. I took this drug for only 2 days & damn near got addicted to it.

  • Reply Robert Ibarra June 3, 2019 at 4:39 am

    I dont understand how people get addicted. I only used 6 for pain and then never needed more as I recovered.

  • Reply Jonny Baron June 5, 2019 at 11:20 pm

    I only had 30mg and sum weed and my misiss found me fitting on the floor . What was that allabout lol

  • Reply Anthony Sonnheim June 7, 2019 at 1:36 am

    It's Good Stuff! I Believe We Have A God With Good Taste………..Amen😇

  • Reply PlumBoss84 June 10, 2019 at 11:09 am

    If it’s “good”, the bad will abuse, making it harder for the use of good.

  • Reply FruityPebs June 10, 2019 at 4:39 pm

    The constipation is really extreme with this.

  • Reply Hugh Haefner June 11, 2019 at 3:58 am

    Oxycontin allowed me to work instead of going on disability for 10 years after a head on 70 mph crash. Spinal cord surgery kept me from being paralyzed but I was left with massive pain. I'm no longer on it because I retired and didn't need that heavy medication anymore. It saved my life and I had no problems with it. Getting off it was horrible but neccesary and I did it cold turkey. It was there when I needed it and then the opiate crisis started because of the junkies that only wanted it to get high. I took them as prescribed and functioned well. Now I hear people that need it are being forced to live in pain and more people are opting for social security disability.

  • Reply Jon Boy June 14, 2019 at 7:53 pm

    It was suggested to me to try weed with my prescribed OxyContin, However It did not go well I stopped breathing, I was in a comatose state when my wife disturbed me I started breathing again I will never mix the two again!! ☠️👻

  • Reply Lg Luigi June 19, 2019 at 11:08 pm

    4:00 I do not I understand exactly what you mean when you say that. Not after what you just said within 10 seconds before that.

  • Reply Lg Luigi June 19, 2019 at 11:11 pm

    4:39 nope, that is incorrect. A strong dose is 30 – 60 mg, and a 25 mg is something that I'm not sure if I even seen one time. I have seen 20 mg.

  • Reply Wayne Wallace June 22, 2019 at 11:10 pm

    I took Oxycodone a year ago due to left shoulder pain until after surgery and it's all repaired. Now after a year later, I can't live without it because it feels so good to be on it. Is there something wrong with that?

  • Reply Stevie Jo June 23, 2019 at 5:05 pm

    First time I ever did oxy. It was a 40mg original green tablet. It was a potent rush. I mean. It was shootable. Almost seems like it was made that way. It was a rush

  • Reply Mark Toledo June 26, 2019 at 6:25 am

    "it seems to act" Mess and kill people up with "Their" BS wars. The messed up survivors, in the millions worldwide then are screwed over by, again, the."Their / Thems/ pharma companies/ bankers and the like who ride high $$$, while us, sheeple to "Them" have our lives ruined, which in turn mess up family dynamics. I'm beyond sick at the whole lot of the "Them" group which our bs gvrnmnt is also part of. A total shame on our country's schematics. Hopefully with the likes of social media, a hero of the ages can unite many of the non-1%'rs to snowball a steamrolling positive outcome for the real American Hard working people. Just an idea I dream about.

  • Reply zac Niebling June 26, 2019 at 3:44 pm

    BE VERY, VERY CAREFUL WITH OPIOIDS KIDS!

  • Reply Wil Hathaway June 29, 2019 at 6:03 am

    Oxycodone

    Positive side effects: fucking loving life

    Negative side effects: not having enough pills 😞

  • Reply James June 29, 2019 at 11:51 pm

    I get 120 10mg a month. Screw you evil government.

  • Reply Vallis Daemonum July 1, 2019 at 2:29 am

    [LIL WYTE WANTS TO KNOW YOUR LOCATION]

  • Reply Steve Tanner July 3, 2019 at 8:49 am

    I would rather take CBD pfffffttt NOT!!!!!

  • Reply Steve Tanner July 3, 2019 at 9:06 am

    I never done drugs much in my young life maybe a little weed and alcohol now and then I started in the workforce at 16 I am now 54 when I hit 40 my joints started aching and other pains I never felt before I started getting burnout from working every day depression and aggravation just from lifes every day grind but when I got prescribed an oxy things got a whole lot better I tried depression meds they were a joke it's the only med that has ever helped weed made me paranoid alcohol made me sick and tired

  • Reply Steve Tanner July 3, 2019 at 9:14 am

    Of course it is addicting isnt everything that makes you feel good addicting including sex food etc DUH!!

  • Reply Jay K July 3, 2019 at 11:04 pm

    Morphamphetamine??

    Wide Awake Passed Out

  • Reply Jon Mcmann July 9, 2019 at 8:04 am

    this narrator sounds like the guy from Zach Morris is Trash

  • Reply Austin Santos July 11, 2019 at 2:43 pm

    Anyone want off Oxycodone please try KRATOM

  • Reply King July 15, 2019 at 12:48 am

    I’ve been prescribed for sickle cell pain, but they’re good for sleeping

  • Reply Thrashin alex July 17, 2019 at 7:41 am

    can you take expired oxys and still get high ?

  • Reply Teebo Lurdo July 18, 2019 at 11:44 pm

    I'm attempting to wean Norco, have gone from 7 a day down to 3 , or even 2.5
    10mg/325. I'm doing pretty good, never touch them till after 4pm now and may only have weed or gabbapentin during the day. My best friend may be dead anyday from Oxy use
    And I crave to have a life where I over come addiction on my own, through spirituality, diet, and whatever however….
    My back and neck are pretty bad but I am
    Trying to be my best

  • Reply Wezilla July 21, 2019 at 10:35 am

    What if I take 50mg in 1 go ?

  • Reply Wezilla July 21, 2019 at 10:36 am

    I'm kinda addiction
    It so good to get drowsy and calm…

  • Reply Tiffany Elliott August 3, 2019 at 11:18 pm

    They arent working for me…

  • Reply Kieran Byrne August 8, 2019 at 1:07 am

    i took 2 oxys 4 and a half hours ago. You think im ok to drink?

  • Reply Healthy Lifestyle August 11, 2019 at 1:31 pm

    I've felt compelled to share this with you guys, and my channel is about losing weight, staying fit and intermittent fasting but i've seen so many of my clients going through really back pain and anxiety when doctors refuse to prescribe them their medication. It's so sad. Most of the time, I refer them to a lady I have met a long time ago in New York who's legit and very reliable that has helped me with my back pain, Just text her 786-309-9508 if you need help. She's got everything you might need for back pain, sleeping aid and anxiety medications. Also, she's got natural alternative medicine. Take care and Blessing.

  • Reply Zach Minder August 13, 2019 at 12:55 pm

    I used to snort these, not fun. Hella blues and greens lmao

  • Reply Colin Kelly August 16, 2019 at 6:26 pm

    Wait what’s the main side effects tho like if u were gonna get high off a 30 mg or something

  • Reply Sleavo August 17, 2019 at 10:25 pm

    Bro i threw Up When I Took This Shit And Then I Fucking Went To Sleep. Like Lmao. Nausea was the worst shit ever. Like That’s All I Felt. It Didn’t Give Me A Good vine so i’m not taking anymore. NEXT PERC.

  • Reply DrakoFury August 19, 2019 at 2:10 pm

    Music enhancement?

  • Reply Hazel Reed August 21, 2019 at 12:01 am

    WHAT IS 512

  • Reply Roadrunner August 24, 2019 at 10:30 pm

    I have prescriptions for sell

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